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Figure 1 Methods of data handling with missing data on progression.

At least nine events are related in assessing PFS: I. Local regional relapse; II. Distant metastases; III. Second primary tumor-same entity; IV. Second primary tumor-other entity; V. *Death related to tumor; VI. *Death related to another tumor; VII. *Tumor independent death; VIII. *Death related to tumor therapy; IX. Lost to Follow-up: Censored. All events marked by * are also covered by OS ( MCM Monogram Print Crossbody Bag Brown 0WLDN
) ( Liviana Conti Knee Length Dresses Camel shpr3

Figure 2 All events of OS are covered by PFS; PFS shows additionally the events of tumor control.

To demonstrate the impact of sample size Figure 3 illustrates calculation for trials where the surplus in overall survival varies. Sample size is calculated by the log rank test (Freedman) under the assumption that in the two groups the hazards are proportional (PASS 11, version 11.0.7, 2011) ( 42 , 43 ). Further on, it is assumed that the survival times are exponentially distributed. If the median survival of the control group is 12 months then the 1-year survival rate is 50%. An increase of 10% to a 1-year rate of 55% is equivalent to a survival of 14 months. A rate of 60% corresponds to 16.3 months, 65% to 19.4 months, and 70% to 23.4 months, nearly doubling the survival time. For superiority the one-sided test is used. The power was set to 90% or 80% and α=0.025 or α=0.05. Accrual is 1 : 1 for the two groups. The sample sizes vary between N=4059 and N=151 depending on the power, significance and survival proportion. A small incremental increase in survival time accompanied by small error rates (power and α) leads to a large study population.

Figure 3 Sample size calculation for proportion of 1-year survival of 0.55-0.70 of experimental group versus 1-year survival of 0.5 for controls in a 1:1 recruitment and with power of 80% or 90% and α=0.025 or α=0.05.

The main factor for PFS to predict OS is the duration of PFS ( 43 ). A significant survival gain can be predicted in a trial of 750 patients if 18% of patients responding to treatment. 500 patients are needed if 21% of patients respond and if it is postulated that 30% patients respond, at least 250 patients must be enrolled.

The necessary incremental gain for PFS to predict a survival improvement was a median of 1.7 months for trials with 750 patients, 2.2 months for 500 patients, and 3.3 months for trials with 250 patients. Hence, a significant surplus on PFS can only be predictive for OS if the sample is big enough. Statistically it comes to compare PFS and OS as two failure time distributions in the presence of censoring, where the distribution is shifted due to the different time interval of measurement ( 44 ). Compared to OS in PFS more competing risks are included ( Figure 2 ). PFS as surrogate endpoint for OS can also be investigated by the aid of a stochastic model ( 45 ). The Process was demonstrated theoretically by a statistical OS model with two independent stochastic processes defining an interim and a restart point of progression. Since it has been discovered that the interval after progression to death may have similar distribution for most of the lung cancer trials PFS as a surrogate of OS seem to be reasonable ( Patrizia Pepe Booties Gold vrr7If
, 47 ). The strongest prediction of PFS for OS results from a high correlation of PFS and OS and a high treatment effect homogeneity ( Figure 4 ).

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Ultimate Travel Guide To Vietnam Cambodia Laos

» Destination » Stelen Aren Dress Black nSycOEq4Ax
» Vietnam by Month » Best places to visit in Vietnam in December

December is the most beautiful time to visit Vietnam with mild climate and pleasant in every region of the country.

December most beautiful time to visit Vietnam

You will experience sunny days with a touch of wind in attractive beaches and spectacular sites in the South and the Center. The North may cooler than the South and the South with low temperature.

Vietnam in December is suitable for visiting and traveling in beautiful beaches and attractive sites in the Center and the South, hiking or climbing in the North’s highland areas.

Vietnam in December

The North of Vietnam in December is in the winter time with the low temperature, about 20oC with bright, windy sky.

The Central: The rainfall has decreased, the sunny days almost return in the attractive beaches. The average temperature is 24oC with clear sky.

The South area is returning to the sunny days, with the average temperature is 26oC with clear sky.

1. Moc Chau

Moc Chau plateau, located about 200 km west of Hanoi , is one of Vietnam’s most attractive places in December. Despite the cold winter, Moc Chau Plateau maintains its stunning beauty with a wide variety of flowers and down in the valleys.

Moc Chau

Yellow wild sunflowers and white mustard flowers lend color to the landscape around Moc Chau.In the weeks before Tet holiday , there are vast forests of blossoming plum trees, especially around Kia Cave, Paco, and Tan Lap, where the white plum flowers are so numerous that they are like snow blanketing the valleys.

In Moc Chau, you can visit tea farms and learn how to pick tea leaves, dry them and then brew a cup.

You can also sample local specialties like fried beef, fish and fresh milk. Thanks to such attractions, Moc Chau is the number one choice of travelers at this time of the year.

“A 3-day tour of Moc Chau is the perfect choice. Three days gives visitors enough time to explore nearby destinations like Tan Lap commune, Nong Sap, and the caves of Ban on, Ta Phinh and Ta So”said by Mai – a travel expert at Jimmy Choo Margo Leather Lace Up Sandals Tan DSFJp9

December is the best time for trekking to conquer Pha Luong peak to chase the clouds and take stunning pictures.

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